Buy Janumet XR Online
Janumet XR is an oral medication that includes a combination of two antidiabetic medications, metformin and sitagliptin. It is indicated in adults with type 2 diabetes mellitus (T2DM) to improve glycemic control in addition to diet and exercise. Controlling hyperglycemia prevents downstream complications such as kidney damage, loss of limbs, blindness, heart attack, stroke, or nerve problems. It is important that diabetes remains controlled to lessen the chance of related complications. Janumet XR is not indicated for the treatment of type I diabetes.
HOW DOES JANUMET XR WORK?
Metformin, a biguanide, and sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, work together through a complementary mechanism to improve glycemic control. The individual components of Janumet XR work in the following ways:
Incretin hormones are important in glycemic control and include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). After meals, the intestine releases these incretin hormones in response to increased blood glucose concentrations. These hormones stimulate insulin release from pancreatic beta cells, thus regulating the blood glucose levels. However, GLP-1 and GIP can be inactivated by an enzyme called DPP-4. Sitagliptin inhibits DPP-4, thus increasing incretin hormone levels and insulin release to mediate blood sugar levels.
Metformin is a biguanide that lowers the production of hepatic glucose, lowers absorption of glucose in the intestine, and improves insulin sensitivity through increasing peripheral glucose. Insulin release does not change with metformin, however, fasting levels of insulin and day-long plasma insulin response can be lowered.
Common side effects include:
Nausea, vomiting, or stomach upset
Diarrhea or constipation
Joint or muscle pain
A metallic taste in the mouth
Cold symptoms such as runny or stuffy nose, sneezing, and sore throat